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(pathology) A chronic disease marked by enlargement of the bones of the extremities, face, and jaw that is caused by over-activity of the pituitary gland.

Lower jaw showing the classic spacing of teeth due to acromegaly.

(pathology) A chronic disease marked by enlargement of the bones of the extremities, face, and jaw that is caused by over-activity of the pituitary gland.

Compared with the hand of an unaffected person (left), the hand of a person with acromegaly (right) is enlarged, with fingers that are widened, thickened and stubby, and with thicker soft tissue

(pathology) A chronic disease marked by enlargement of the bones of the extremities, face, and jaw that is caused by over-activity of the pituitary gland.

Mandibular overgrowth leads to prognathism, maxillary widening, teeth spacing and malocclusion