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(biochemistry, medicine) A receptor, situated in the terminal of a presynaptic nerve cell, that is sensitive to neurotransmitters released by the neuron in whose membrane the autoreceptor sits.

This diagram shows pre-synaptic neuron (left) releasing a neurotransmitter, noradrenaline (norepinephrine), into the synaptic cleft. The transmitter acts on the receptors of the post-synaptic neuron (right), but also on autoreceptors of the pre-synaptic neuron. Activation of these autoreceptors typically inhibits further release of the neurotransmitter.

(biochemistry, medicine) A receptor, situated in the terminal of a presynaptic nerve cell, that is sensitive to neurotransmitters released by the neuron in whose membrane the autoreceptor sits.

Amphetamine, trace amines, and dopamine can activate TAAR1 in dopamine neurons, but only dopamine activates D2sh. These receptors have opposite effects on protein kinase signaling. This results in opposite effects on DAT phosporylation, and consequently, on reuptake as well.