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Kuvat 1

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Määritelmät

Substantiivi

  1. (biochemistry) A complex of proteins, first identified in yeast, which plays an important role in recycling transmembrane receptors from endosomes to the trans-Golgi network.

Samankaltaisia sanoja

Taivutusmuodot

Monikkoretromers

Luokat


(biochemistry) A complex of proteins, first identified in yeast, which plays an important role in recycling transmembrane receptors from endosomes to the trans-Golgi network.

Model of the retromer heteropentameric complex (VPS26 in green; VPS35 in orange, and VPS29 in red). The retromer forms a polymeric network arc on the outside (cytoplasmic side) of the endosome tubule. Inside the tubule, the cargo receptor SORL1, forms its own network and binds protein cargo for trafficking. SORL1 connects to retromer on the outside via a transmembrane helix and a short C-terminal tail that binds VPS26. Model built based on structural data by Brett Collins and Yu Kitago.