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- "This latter point is of concern given the high prevalence of von Willebrand disease (1 in 100 individuals) in the United States." - N. A. Goldenberg, L. Jacobson and M. J. Manco-Johnson. Brief Communication: Duration of Platelet Dysfunction after a 7-Day Course of Ibuprofen. Ann Intern Med 2005; 506-509. http://www.annals.org/cgi/content/full/142/7/506