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a thermal analysis technique in which a tiny sample pan is heated together with an empty reference pan and the difference in heat flow between the two measured as a function of temperature.

Differential scanning calorimeter

a thermal analysis technique in which a tiny sample pan is heated together with an empty reference pan and the difference in heat flow between the two measured as a function of temperature.

Top: A schematic DSC curve of amount of energy input (y) required to maintain each temperature (x), scanned across a range of temperatures. Bottom: Normalized curves setting the initial heat capacity as the reference. Buffer-buffer baseline (dashed) and protein-buffer variance (solid).

a thermal analysis technique in which a tiny sample pan is heated together with an empty reference pan and the difference in heat flow between the two measured as a function of temperature.

Normalized DSC curves using the baseline as the reference (left), and fractions of each conformational state (y) existing at each temperature (right), for two-state (top), and three-state (bottom) proteins. Note the minuscule broadening in the peak of the three-state protein's DSC curve, which may or may not appear statistically significant to the naked eye.