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• Inflammation and scarring is a shared mechanism for chemical irritants, cryotherapy, laser thermotherapy, and autologous blood injection in the treatment of bleb dysesthesia, overfiltering blebs, and bleb leaks.
• If the leak allows bulk flow of aqueous, the rest of the bleb can collapse, allowing apposition of the inflamed inner bleb walls, which are likely to adhere. If such adherence is over most or all of the bleb area, bleb failure is probably inevitable.
• Use of intraoperative antimetabolites is a risk factor for the development of a bleb leak.
• The mechanism of a bleb leak is thought to be as follows. Ischemic blebs are stretched and surrounded by heavily scarred tissue, which limits the ability of the aqueous to flow beyond the scarred tissue. The bleb expands locally, producing a tractional hole when the tissue overreaches its maximal stretch.
• Figure 4.20 reveals blebs on the surface of a bacterial cell. In many instances, these blebs are released from the cell into the surrounding media.
• As the bleb grows (the growth time is on order of a minute), the actin cortex starts reassembling beneath the bleb membrane.
• A different approach is to use protrusions from the membrane, which are called blebs or blisters.[...]The absence of actin and tubulin from blebs formed on oocytes of Xenopus laevus clearly indicates the bleb membrane is detached from the cell cytoskeleton (Figure 3.29).
• Figure 23.[...]The crust is underlain by silty sand, which is loosely cemented by a meshwork of gypsum crystals and contains blebs and small nodules of white ulexite (U).
• And there, while big drops bow the grassy stems, / And bleb the withering hay with pearly gems,/ Dimple the brook, and patter in the leaves, / The song or tale ah hour's restraint relieves.
• Cells were blebbed by brief exposure (5-20 s) to 2 M NaCl-NaOH (pH 10.0) and then labeled with rhodamine-conjugated Fab fragments.